Abstract

SummaryMice, adapted to cyclic change of light and darkness (12 hours light, 12 hours darkness) were irradiated at different times within the 24 hours. It was observed that after irradiation during the day (14 hours) the number of endogenous colonies in the spleen was higher than that after irradiation at night (20 hours). The lowest number of colonies in the spleen was observed following irradiation 1 hour after the change of light cycle (8, 20 hours). The dose-survival curves for colonies had higher numbers of colonies at 14 hours than that at 8 hours, but the D0 was similar at both times. The transplantation of bone-marrow and spleen cells indicated a higher colony forming ability for cells from adapted mice killed in the middle of the day, than from those killed soon after change of light cycle.The changes in rectal temperature and oxygen consumption of adapted mice followed a contrary course as compared with changes in the number of colonies in spleen after irradiation at different times of the day. ...

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