Abstract

BackgroundCircadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders.MethodsActigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13–25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria. We examined associations between three easily interpretable markers of circadian rhythm activity (amplitude, acrophase and rhythmicity index) and demography and clinical characteristics. Then, circadian markers were compared between diagnostic groups, controlling for potential confounders.ResultsLonger duration of illness was correlated with reduced circadian rhythmicity and lower levels of activity over 24 h. A delay in the timing of maximum activity was associated with the level of manic but not depressive symptoms. The circadian rhythmicity index differentiated unipolar from bipolar cases, and in bipolar but not unipolar disorder, the rhythmicity was less robust in those with more severe manic or depressive symptoms.ConclusionsLess robust circadian rhythmicity, especially associated with increasing symptom severity, may represent a more specific or a trait marker of young people with mood disorders who are at higher risk of a bipolar course of illness.

Highlights

  • Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms

  • Most investigations of circadian rhythm disruptions in mood disorders are focused on older adult samples with established unipolar (UP) or bipolar disorders (BD)

  • Often these individuals have a history of multiple mood episodes, accompanied by a high prevalence of mental and physical comorbidities, complex treatment regimens and/or elevated body mass index (BMI) (Geoffroy et al 2015)

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Summary

Introduction

Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. Circadian rhythm disturbances are of considerable interest to mood disorder researchers as many of the phenomena that accompany disruptions in the sleep–wake cycle overlap with the symptoms of mood episodes or may trigger or prolong mood symptoms (e.g. McClung 2013; Robillard et al 2013a). Most investigations of circadian rhythm disruptions in mood disorders are focused on older adult samples with established unipolar (UP) or bipolar disorders (BD) Often these individuals have a history of multiple mood episodes, accompanied by a high prevalence of mental and physical comorbidities, complex treatment regimens and/or elevated body mass index (BMI) (Geoffroy et al 2015).

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