Abstract
The activity of various rat-liver microsomal steroid metabolizing enzymes was shown to follow a circadian rhythm. NADPH: 4-ene-3-oxosteroid-5α-reductase in female rats exhibited a maximum at 18.00 h and a minimum at 6.00 h. The same enzyme in male rats showed a minimum at 18.00h (substrate testosterone) and 12.00 h (substrate corticosterone) and a maximum at 24.00 h. Variations in testosterone hydroxylation and NADPH-cytochrome c reductase activity were only detectable in male rats (maximum at 24.00 h and minimum at 12.00 h). NADH: 4-ene-3-oxosteroid-5α-reductase activity in male and female rats was highest at 6.00 h and lowest at 18.00 h.
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