Abstract
SEVERAL circadian rhythms of hepatic enzymes have been reported1–3, but it has not been possible to analyse the mechanism which determines the oscillation of enzyme activities, even though various factors—such as enzyme synthesis, rate of degradation, action of inhibitors, inactivation by steric alterations, and so on—have been considered4. Rapoport et al.5 have published a study of mouse liver tryptophan pyrrolase and its possible correlation with both substrate and corticosteroid oscillations. They found this enzyme activity rhythm to be corticosteroid-dependent, but could not detect an obvious relation between maxima of substrate, hormone, and enzyme activity. This report tries to identify the controlling factors for increase and decrease in rat liver tryptophan pyrrolase activity during a diurnal period.
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