Abstract
Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.
Highlights
Circadian Genes as Therapeutic Targets in Pancreatic CancerGenes as Therapeutic Targets in Pancreatic Cancer
Pancreatic cancer is the 15th most common malignancy and ranks 7th among malignant cancers in terms of death [1]
In glioblastoma stem cells (GSCs), the clock machinery seems to regulate glucose metabolism and lipid synthesis, while this control is not exerted in normal neural stem cells, being these differences attributed to distinctive changes in chromatin [92]
Summary
Genes as Therapeutic Targets in Pancreatic Cancer. Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. The mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. We revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports
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