Abstract
The distribution of bile acid in the enterohepatic circulatory system at different times of the day was determined in 48 hamsters exposed to a rigid light schedule (6 AM to 6 PM) and fed, ad libitum, for 4 weeks. In each portion of the enterohepatic circulatory system, the relative amount of bile acid was determined 24 hours after an intraperitoneal administration of [3H]taurocholic acid by comparing the radioactivity recovered from that portion with the total radioactivity remaining in the entire system. A circadian fluctuation of the relative bile acid content (percent of total) was observed in serum, liver, gallbladder, and intestinal contents. The patterns of such rhythmic change varied in various segments of the intestinal tract but correlated well with the time sequence of the movement of bowel content. Rhythms in the serum and liver were intimately related to the intestinal absorption of bile acid. Due to its small capacity, the gallbladder played only a minor role in the regulation of such a rhythm.
Highlights
The distribution of bile acid in the enterohepatic circulatory system at different times of the day was determined in 48 hamsters exposed to a rigid light schedule (6 AM t o 6 PM) and fed, ad libitum, for 4 weeks
The patterns of such rhythmic changes vary in various segments of the intestinal tract but correlate with the time sequence of bowel content movement and bile acid absorption
Because of the cyclic storage and discharge of bile by the gallbladder, a greater circadian fluctuation in the distribution of bile acid in the enterohepatic circulatory system might be expected in those species with gallbladders, e.g., hamsters, than in those without, e.g., rats
Summary
The distribution of bile acid in the enterohepatic circulatory system at different times of the day was determined in 48 hamsters exposed to a rigid light schedule (6 AM t o 6 PM) and fed, ad libitum, for 4 weeks. A circadian fluctuation of the relative bile acid content (percent of total) was observed in serum, liver, gallbladder, and intestinal contents. The patterns of such rhythmic change varied in various segments of the intestinal tract but correlated well with the time sequence of the movement of bowel content. The amount of bile acid in the serum, liver, and intestinal content of rats fluctuates with time ( 5 ) The patterns of such rhythmic changes vary in various segments of the intestinal tract but correlate with the time sequence of bowel content movement and bile acid absorption. The present study examines circadian fluctuation of the distribution of bile acid in the enterohepatic circulatory system in hamsters and evaluates its magnitude
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