Abstract
Abstract In common voles (Microtus arvalis) and golden hamsters (Mesocricetus auratus) circadian changes in the susceptibility to acute dosing of rodenticides, zinc phosphide and crimidine, were investigated. Animals were dosed at four different times of day (2.00, 8.00, 14.00, 20.00 h) and mortality, convulsive seizure, latency period to first seizure, and running wheel activity were studied. Both voles and hamsters showed the highest susceptibility to zinc phosphide during the light period. In case of crimidine, circadian pattern of susceptibility was noted only in hamsters with the highest mortality during the beginning of the dark period. The data demonstrate that circadian changes in susceptibility to rodenticides have to be taken into account.
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