Circadian blood pressure pattern in patients with aldosterone-producing adenoma and its associated factors

Abstract

Objective To investigate the circadian blood pressure pattern in patients with aldosterone-producing adenoma. Methods Circadian variation of blood pressure was assessed by 24-h ambulatory blood pressure monitoring (ABPM) in 20 patients with adrenal aldosterone-producing adenoma (APA) and 25 patients with essential hypertension (EH). Results Compared to EH group, the body mass index, serum potassium concentration, upright plasma renin activity and angiotensin Ⅱ levels in APA group were lower and the serum sodium concentration and upright plasma aldosterone concentration were higher (all P 0.05]. Multivariate Logistic regression analysis showed no independent predictors for non-dipper circadian blood pressure pattern. Conclusion There are no significant differences in proportion of non-dipper circadian blood pressure pattern and blood pressure characteristics between APA and EH patients. Key words: Hyperaldosteronism, primary; Aldosterone producing adenoma; Ambulatory blood pressure monitoring