Abstract
Circular RNAs (circRNAs) might participate in the growth of cervical cancer (CC). In this research, we reconnoitered the characters of circ_0031027 in CC. Circ_0031027, microRNA-587 (miR-587), and suppressor of cytokine signaling 5 (SOCS5) abundances were distinguished by qRT-PCR and western blot. The cell functions were examined by colony formation assay, EdU assay, and transwell assay. The combined relationship of miR-587 and circ_0031027 or SOCS5 was identified by dual-luciferase reporter assay. Ultimately, the mice test was utilized to assess the part of circ_0031027. Circ_0031027 and SOCS5 were downregulated, and the miR-587 was upregulated in CC. For functional analysis, circ_0031027 overexpression repressed cell proliferation, cell migration, and invasion in CC cells. Circ_0031027 as a miR-587 sponge to adjust SOCS5. MiR-587 facilitated the advancement of CC cells by overturning SOCS5. In addition, circ_0031027 overexpression subdued tumor growth. Circ_0031027 inhibited the enlargement of CC by miR-587/SOCS5.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
