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Abstract
Spleen cells from C3H/HeN mice treated with BCG or Mycobacterium smegmatis displayed similar increased antibody-dependent cellular cytotoxicity (ADCC) in vitro. This activity, which increased between the tenth and the thirty-first day after stimulation, reached twice the amount of ADCC activity developed by the control spleen cells. C3H/HeN mice treated with a complete adjuvant including M. smegmatis and squalane displayed a lower increase in their ADCC capacity (30% instead of 100%). Les cellules spléniques de souris C3H/HeN traitées par Mycobacterium smegmatis selon différents protocoles ont une activité ADCC (CCDA) (cytotoxicité anticorps-dépendante à médiation cellulaire) accure envers des globules rouges de poussin, selon une cinétique identique et dans des proportions semblables à celles observées au cours d'un traitement par le BCG. Ces résultats peuvent être rapprochés de l'effet antitumoral exercé in vivo par ces deux immunostimulants.
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