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Abstract
ScopeCinnamon is associated with anti‐obesity effects, regulating food intake, improving plasma glucose levels and lipid profiles in vivo. In the present study, the impact of cinnamyl isobutyrate (CIB), one constituent of cinnamon, on ad libitum food intake from a standardized breakfast and outcome measures of hormonal regulation of appetite were investigated.Methods and resultsIn this randomized, short‐term crossover intervention study, a 75 g per 300 mL glucose solution solely (control) or supplemented with 0.45 mg CIB was administered to 26 healthy volunteers. Prior to and 2 h after receiving control or CIB treatment, subjective hunger perceptions were rated using a visual analog scale. Food intake from a standardized breakfast was assessed 2 h after treatments. Plasma peptide YY3–36, glucagon‐like‐peptide1, ghrelin, and serotonin as well as plasma glucose and insulin were measured in blood samples drawn at fasting and 15, 30, 60, 90, and 120 min after treatment. CIB administration decreased total energy intake and delta area under curve plasma glucose by 4.64 ± 3.51% and 49.3 ± 18.5% compared to control treatment, respectively.ConclusionsCIB, administered at a 0.45 mg bolus in 75 g glucose–water solution, decreased ad libitum energy intake from a standardized breakfast and postprandial plasma glucose levels.
Highlights
Plasma peptide YY3–36, nals as well as enhancing energy expendiglucagon-like-peptide1, ghrelin, and serotonin as well as plasma glucose and insulin were measured in blood samples drawn at fasting and 15, 30, 60, 90, and 120 min after treatment
We studied whether a bolus dose of 0.45 mg cinnamyl isobutyrate (CIB) has an impact on the ad libitum energy intake from a standardized breakfast, subjective hunger perceptions, and on postprandial blood glucose levels in moderately overweight volunteers following an oral glucose tolerance test (OGTT) with or without CIB supplementation
Cinnamon has previously been linked to beneficial health properties, including improved blood glucose levels,[13,15,37,38] insulin sensitivity[39,40] as well as serum lipid profiles,[7] and to maintenance of body weight and body composition.[15,16]
Summary
1. Introduction intake, improving plasma glucose levels and lipid profiles in vivo. In the present study, the impact of cinnamyl isobutyrate (CIB), one constituent of cinnamon, on ad libitum food intake from a standardized breakfast and outcome measures of hormonal regulation of appetite were investigated. Combating the rising prevalence of overweight and obesity, associated with an increased risk of developing various comorbidities, has become a worldwide challenge.[1,2,3] Therefore, medical treat-
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