Abstract
Sirtuins (SIRTs) may play a role in aging, insulin sensitivity, lipid metabolism, stress responses, and inflammation. Cinnamon type A polyphenols (CPA) have also been shown to improve glucose, insulin, and lipid metabolism, and inflammation. However, little is known of the effects of CPA on the expression of SIRTs. In this study, Wistar rats were fed a fructose‐rich diet for 6 weeks to induce insulin resistance and freshly isolated intestinal enterocytes were used to investigate the effects of purified CPA in vitro on SIRTs genes by RT‐PCR and proteins by Western blot analyses. SIRT1, 2, 3, 5, and 7 gene expressions were increased by 20 and 100 μg/mL CPA after 2 and 4h treatment; SIRT1‐3 protein levels were higher in 100 μg/mL CPA‐treated enterocytes after 4h. Similar effects were observed in the small intestinal enterocytes isolated from older Wistar rats (65 wks) consuming a stock diet. These results suggest that cinnamon polyphenols may activate sirtuins in intestinal enterocytes functionally altered by diet and age (Funded by USDA CRADA No.58‐3K95‐7‐1184 with Integrity).
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