Cinnamon modulates biochemical alterations in rats loaded with acute restraint stress

Abstract

The present study was undertaken to investigate pretreatment efficacy of cinnamon (Cinnamomum zeylanicum) on blood glucose level as well as oxidative changes at the liver level.Following acute restraint stress, the experimental animals (n=6) were randomly assigned into four groups, i.e., non-stressed control, stress control and treatment groups (cinnamon decoction 10%, 3 and 6ml/kg, p.o, for 7days). Anti-stress effect of cinnamon was studied by estimation of blood glucose level, liver marker enzymes; aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase, liver reduced glutathione (GSH) and liver antioxidant enzymes; super oxide dismutase (SOD), glutathione-S-transferase (GST), catalase (CAT) and glutathione reductase (GR). Acute restraint stress was evidenced by reduction of blood glucose level and liver GSH and elevation of liver marker enzymes in serum. In addition, antioxidant enzymes were drastically inhibited in liver homogenate of stress control rats. Pre-treatment with cinnamon decoction 10%, (3ml/kg and 6ml/kg, p.o, for 7days) avoided the changes observed in stress control rats. This study substantiates that cinnamon is effective in minimizing stress responses thereby beneficial in stress therapy.