Abstract
Background and Aim:Hyperlipidemia is an important risk factor for cardiovascular disease. The use of statins has adverse side effects that result in oxidative stress disorders. The objective of this study was to investigate the antihyperlipidemic effect of a combination of Cinnamomum burmannii and Eleutherine palmifolia extract in high-fat diet (HFD)-induced hyperlipidemia mice.Materials and Methods:Mice were divided into eight groups (n=4): Control group or healthy mice (normal), HFD-induced hyperlipidemic mice without any treatment (CE0), HFD-induced hyperlipidemic mice treated with 3.6 mg/kg body weight (BW) atorvastatin (atorvastatin), and HFD-induced hyperlipidemic mice treated with a combination of C. burmannii and E. palmifolia in the following ratios: 300:0 (C300), 225:75 (C225), 150:150 (CE150), 75:225 (E225), and 0:300 (E300). Mice were fed a HFD for 4 months to induce hyperlipidemia. Total cholesterol, cholesterol oxidase-peroxidase aminophenazone (CHOD-PAP), triglyceride-glycerine, and fat serum were analyzed with colorimetric method. The measurement of superoxide dismutase was done with the xanthine oxidase method and malondialdehyde measurement was done with the thiobarbituric acid method.Results:Results showed an increase in antihyperlipidemic characteristics as the concentration of E. palmifolia extract (p<0.05) increased. Duncan’s multiple range test also showed an increase in anti-stress oxidation as the concentration of C. burmannii extract (p<0.05) increased.Conclusion:The E225 group showed the most potential as a safe, antihyperlipidemic agent characterized by improvement in lipid profile and antioxidant balance.
Highlights
Hyperlipidemia is a medical condition characterized by the elevation of any or all lipid profiles and/or lipoproteins in the blood and is called hypercholesterolemia or hyperlipoproteinemia [1,2]
Materials and Methods: Mice were divided into eight groups (n=4): Control group or healthy mice, HFDinduced hyperlipidemic mice without any treatment (CE0), high-fat diet (HFD)-induced hyperlipidemic mice treated with 3.6 mg/kg body weight (BW) atorvastatin, and HFD-induced hyperlipidemic mice treated with a combination of C. burmannii and E. palmifolia in the following ratios: 300:0 (C300), 225:75 (C225), 150:150 (CE150), 75:225 (E225), and 0:300 (E300)
The E225 group showed the most potential as a safe, antihyperlipidemic agent characterized by improvement in lipid profile and antioxidant balance
Summary
Hyperlipidemia is a medical condition characterized by the elevation of any or all lipid profiles and/or lipoproteins in the blood and is called hypercholesterolemia or hyperlipoproteinemia [1,2]. Elevated low-density lipoprotein cholesterol (LDL-C) is thought to be the best indicator of atherosclerosis risk, hyperlipidemia can be determined by elevation of total cholesterol (TC) or triglyceride (TG) levels, or by low levels of high-density lipoprotein-C (HDL-C) [3]. Elevated LDL-C and TGs in hyperlipidemia correlate to cardiovascular disease (CVD), diabetes [4], and hypertension [5]. Hyperlipidemia is an important risk factor for cardiovascular disease. The objective of this study was to investigate the antihyperlipidemic effect of a combination of Cinnamomum burmannii and Eleutherine palmifolia extract in high-fat diet (HFD)-induced hyperlipidemia mice
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
