Cinnamomum burmannii Bl. Bark Ameliorate Lipid Profile and Platelet Aggregation in Dyslipidemia Mice through Antioxidant Activity

Abstract

BACKGROUND: Cinnamomum burmannii Bl. has a higher coumarin, flavonoids, saponins, and alkaloids. AIM: We investigated the antioxidant, anti-platelet aggregation, and anti-dyslipidemia activity of cinnamon bark extract (CBE) in dyslipidemia mice. METHODS: Mice were divided randomly into six groups (n = 5) that consist of normal control, negative control, positive control (atorvastatin), and test groups of CBE at doses 300, 400, and 500 mg/kg BW. All groups except normal control were given dyslipidemic-induced feed for 14 days. After that, the induction of dyslipidemia was stopped, then continued with suspension of atorvastatin (positive control) and the test group was given CBE for 7 days. Then, it was measured malondialdehyde (MDA), superoxide dismutase (SOD), bleeding time, coagulation time, total cholesterol, triglyceride, low density lipoprotein (LDL), and high-density lipoprotein (HDL). RESULTS: The CBE has antioxidant activity by decreased MDA concentrations and increased SOD activity in dose group 300; 400; and 500 mg/kg BW compared to negative control. The anti-platelet aggregation of CBE showed that the effects of prolong bleeding time and coagulation time and improve the decreased plasma absorbance after the addition of ADP. There was a decrease in total cholesterol for the three dose groups, respectively, 20.14%, 24.42%, and 35.76%. Triglyceride levels decreased by 4.09%, 8.74%, and 12.5%. LDL levels decreased by 38.17%, 53.8%, and 67.96%. HDL levels increased by 27.29%, 67.8%, and 72.64%. CONCLUSION: CBE has antioxidant, anti-platelet aggregation and anti-dyslipidemia activity, and potential to prevent cardiovascular disease.