Abstract
IntroductionIn this study, a novel use of Cinnamaldehyde in protection of brain oxidative stress was explored. MethodsMale Wistar rats were placed on either a high fat diet (HFD) or a normal diet, starting at 12 weeks of age and lasted for 16 weeks to establish metabolic syndrome. Then, Cinnamaldehyde (20 mg/kg) was daily given orally for 24 weeks. Malondialdehyde and nitric oxide metabolites (NOx) were evaluated in cerebellum, hippocampus, and cortex. ResultsThe HFD increased malondialdehyde in serum and the brain. Although, NOx concentration was increased in cerebellum, it decreased in serum and adrenal. Cinnamaldehyde lowered lipid peroxidation in serum and brain of HFD rats. Moreover, it restored NOx alterations in adrenal and cerebellum. ConclusionThe results of the present study provide evidence supporting beneficial effects of Cinnamaldehyde on brain disorders associated with metabolic syndrome and aging.
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