Abstract
Changes in high-density lipoprotein (HDL) cholesterol levels were monitored in five patients treated with cimetidine for gastrointestinal disturbances. A progressive rise of HDL cholesterolemia, statistically signficant after four weeks of treatment and highly so after eight weeks (+ 25.4%) was noted. The composition of HDL 2 varied insignificantly, whereas a marked rise of HDL 3 cholesterol (+ 23.4%) and protein (+ 13.9%) was observed at the end of eight weeks. Cimetidine seems to act in a similar way as microsomal enzyme inducers, in spite of the described inhibition of specific pathways in drug metabolism; recent evidence shows that cytochrome P-450 turnover is delayed after cimetidine. Whatever the mechanism(s), H 2 receptors may play a role in the cholesterol removal from tissues.
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