Abstract
OBJETIVO: Determinar as características de eluição da gentamicina. MÉTODO: 480mg de gentamicina foram adicionadas a 40g de cimento ósseo. Dez corpos de teste semelhantes foram produzidos e imersos individualmente em solução salina tamponada por 28 dias. Amostras dos dias 1, 2, 7, 14, 21 e 28 foram analisadas pelo método de imunofluorescência polarizada. RESULTADO: A maior parte da gentamicina foi liberada do cimento nas primeiras 24 horas. Uma queda gradual se deu do 2° ao 14° dia. No 28° dia, a maior parte das amostras não apresentava mais níveis detectáveis do antibiótico. CONCLUSÃO: A mistura liberou quantidades elevadas e em doses terapêuticas do antibiótico de forma previsível ate o décimo quarto dia.
Highlights
Bone infection treatment is a major therapeutic challenge and the strategy most frequently used is a combination of surgical debridement and antibiotic use
The use of antibiotic associated with polymethylmethacrylate (PMMA) as carrier agent was adopted for the first time by Buchholz et al.[6] for prophylaxis and treatment of infection in hip arthroplasties
Nelson et al.[9] compared the use of gentamicin beads associated with systemic antibiotic for five days, versus systemic antibiotic for six weeks, in the treatment of infection in hip and knee prostheses, with a lower rate of reinfection with the use of local antibiotic (15% versus 30%)
Summary
Bone infection treatment is a major therapeutic challenge and the strategy most frequently used is a combination of surgical debridement and antibiotic use. The prophylactic use of gentamicin beads associated with systemic antibiotic in the treatment of exposed fractures reduced the rate of infection from 17 to 4%10 and the method has been described successfully in the treatment of infected bone defects.[11,12,13,14] Many factors are involved in antibiotic release by PMMA. Cement properties such as composition, porosity and quantity of the monomer, interact with environmental factors, such as tempera-
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
