Abstract
The hormonal control of ciliogenesis and transformation of mucous cells was studied in the oviduct (magnum) of ovariectomized quails. Estradiol benzoate induces ciliogenesis with doses varying from 10 mug/day to 100 mug/day after 6 days of treatment. With 100 mug/day, differentiation of some mucous cells is also induced as well as the formation of transitory "mixed cells" which are in the process of ciliogenesis and contain mucous granules. Associated with progesterone (1 mg/day), estradiol benzoate (10 mug/day) induces the differentiation of mucous cells and ciliated cells. The luminal epithelium of quails injected with this mixture is similar to the luminal epithelium observed in the oviduct of laying quails. With the same dose of progesterone (1 mg/day) and 20 mug/day of estradiol benzoate for 6 days, ciliogenesis is completely inhibited. All epithelial cells are secretory cells. Transformation of 50% of the mucous cells into ciliated cells is obtained by following the previous estradiol-progesterone treatment with the injection of estradiol benzoate (20 mug/day) for 3 days. Divisions of mucous cells were also observed. It is also possible to induce ciliogenesis in some mucous cells by withdrawing both hormones for 3 days. In this case, no cell divisions were observed.
Highlights
Associated with progesterone (1 mg/day), estradiol benzoate (10 txg/day) induces the differentiation of mucous cells and ciliated cells
Transformation of 50% of the mucous cells into ciliated cells is obtained by following the previous estradiol-progesterone treatment with the injection of estradiol benzoate (20 /zg/day) for 3 days
En effet dans les cellules EpithEliales de l'ut6rus de rate, la castration entaine la formation d'un cil unique ~ partir d'un des centrioles, et l'injection d'oestrog6ne provoque des mitoses mais les cellules perdent leur cil unique avant de se diviser [20]
Summary
Associated with progesterone (1 mg/day), estradiol benzoate (10 txg/day) induces the differentiation of mucous cells and ciliated cells. Dans le but de d6montrer la transformation de cellule h mucus en cellule cili6e, nous avons cherch6 ~ reproduire et ~ g6n6raliser ces transformations par des traitements hormonaux chez des cailles castr6es. En injectant des doses faibles d'oestrog~nes (10-20 ~zg/jour), on provoque rapidement la ciliogen~se dans de tr~s nombreuses cellules 6pith6liales et apr~s 6 jours de traitement au moins 50% des cellules sont cili6es (Fig. 2).
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