Abstract
Ciliary Neurotrophic Factor Disturbances in Patients with Melancholic Depression
Highlights
Ciliary neurotrophic factor (CNTF) concentration in blood serum was assessed by ELISA method using Thermo scientific multiskan FC (China) and Human Ciliary Neurotrophic Factor ELISA kit, Cat
Before any treatment CNTF concentration in blood serum of patients with melancholic depression was 679.11 ± 63.09 pg/ml of serum. It was significantly for 71.7 % higher in comparison with healthy subjects (405.96 ± 91.91 pg/ml of serum, p
Earlier we have shown that CNTF concentration was increased in patients with epilepsy [5, 6]
Summary
There were investigated 27 patients with melancholic depression at admission in the clinic of affective disorders of Moscow Research Institute of Psychiatry and 11 healthy volunteers (controls). Patient’s state was defined as a depressive episode in the frame of bipolar depressive disorder (type 2) (F32) and in the structure of recurrent depressive disorder (F33). Investigation was performed in accordance with Helsinki Declaration and the conclusion of local ethical committee of the Institute (No 16 of 13.03.2017).
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