Abstract
The main pathogenesis of nasal allergy lies in the immunological response of allergens and specific IgE antibodies. However, non-specific pathology of nasal mucous membrane induced by recurrence of type I allergy on the nasal mucous membrane might exert various influence on the nasal allergy.Such being the case, in order to examine the pathophysiology of nasal allergy mucosa, the ciliary activity of the inferior turbinate mucosa of 35 patients with nasal allergy and 4 normal persons were investigated by the photo-electric method in the present work. From the present study, the following results were obtained.1. The mean value of ciliary beating frequency on the inferior turbinate mucona in normal persons was 753±46.2. In 32 of 35 cases with nasal allergy, ciliary activity of the nasal mucosa was observed, and the mean value of the ciliary beating frequency was 544±128.3. From a multivariate analysis of the present data, the ciliary activity of nasal allergy mucosa had a close correlation with how long the patients have been suffered from nasal allergy and what type of nasal allergy they are.It has been suggested from the present work that ciliary activity of patients with nasal allergy is declined and the reduced ciliary activity of nasal mucosa may complicate the pathology of nasal allergy. Therefore, the significance of possible consideration of the pathophysiology of nasal mucosa in the treatment of nasal allergy has been strongly suggested.
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