Abstract
Cilia develop long-lasting contacts, with other cilia
Highlights
The primary cilium has been much celebrated for its central role as a sensory organelle
A scanning electron microscopy study from the LaRusso lab observed exosomes in close apposition to cholangiocytes in ciliated bile ducts, and showed that isolated exosomes containing polycystin-1, -2, and fibrocystin can efficiently bind to cholangiocyte cilia [4,5]
The study suggested that membrane bound structures can associate with the ciliary membrane, and that specific paracrine effects of exosomes might be mediated by binding to cilia
Summary
The primary cilium has been much celebrated for its central role as a sensory organelle. At the distal end of the cilium, the ciliary tip is a specialized segment of membrane that extends from the axoneme, and may serve a specialized function in signalling. The study suggested that membrane bound structures can associate with the ciliary membrane, and that specific paracrine effects of exosomes might be mediated by binding to cilia.
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