Abstract
Measurement of intracellular Ca 2+ concentration ([Ca 2+] i) in cultured mouse NG108-15 neuroblastoma × glioma hybrid cells, using the fluorescent probe fura-2, revealed that 5–25 nM ciguatoxin (CTX) increased [Ca 2+] i either in cells bathed in standard medium or after removal of external Ca 2+ by a Ca 2+-free medium supplemented with EGTA. Tetrodotoxin prevented the CTX increased [Ca 2+] i suggesting that CTX-induced mobilization of intracellular Ca 2+ depends on Na + influx through voltage-gated Na channels. CTX-induced Ca 2+ mobilization prevented subsequent action of bradykinin (1 μM) suggesting that CTX stimulates the inositol 1,4,5-trisphosphate-releasable Ca 2+ store.
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