Abstract
Cigarette smoke exposure inhibit antibody production via inhibition of alveolar macrophage
Highlights
Alveolar macrophages (AM) play an important role in the immune system of the lung
Since antibody production has been reported to be inhibited by Cigarette smoke (CS), we investigated the effect of CS exposure on AM at induction and expression phases of antibody production
Since CS inhibited antibody production, we investigated the effect of CS on the expression of surface antigens associated with antigen presentation
Summary
Cigarette smoke (CS) is known to suppress antibody production, but the related mechanism with AM is not clearly understood. The aim of this study was to investigate how CS affects antibody production through alveolar macrophage. Cigarette smoke (CS) consists of mainstream smoke, sidestream smoke, growing smoke, diffusion smoke, effusion smoke, smoldering smoke and blowing smoke, which are exhaled by a smoker [1,2]. CS has a gas phase and a particle phase. Carbon monoxide and ammonia are part of the gas phase. The particle phase includes nicotine and benzopyrene. A major risk factor for development of cancer, has been associated with an increased incidence of infections, chronic pulmonary obstructive disease (COPD), asthma and bronchitis [5,6]
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