Abstract
This is the second reported attempt to demonstrate that cigarette smoke can induce pulmonary emphysema in rats. The negative results have been scrutinized to determine the significance of the changes in airway resistance and content of biogenic amines during exposure to cigarette smoke. These changes in the lung are not important in determining the appearance or disappearance of pulmonary emphysema in rats. In the same animal species, tracheal ligation and endotracheal injection of papain produce pulmonary emphysema.
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