Abstract
The aim of current study was investigated the effects of chrysin supplementation (10 mg/kg, per oral, p.o.) over 28 days in a model of Parkinson’s disease (PD) induced by 6-hydroxydopamine (6-OHDA), using C57BL/6 male mice. Intrastriatal 6-OHDA microinjection caused oxidative stress, impairment of antioxidant defenses, depletion of dopamine (DA) and its metabolites, loss of tyrosine hydroxylase neurons (TH+) of substantia nigra pars compacta (SNpc) and behavioral changes. Chrysin supplementation protect against oxidative stress and depletion antioxidant defenses. Moreover, supplementation with chrysin prevented the decrease of DA and its metabolites, corroborating protection against loss of TH+ neurons in SNpc, blocking behavioral changes induced by 6-OHDA.
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