Chrysin's Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.

Abstract

The purpose of this research was to investigate the effect of chrysin on one of the natural antioxidants on aging progression in an animal model. Oxidative stress and inflammation increase in hepatic tissue during aging, leading to liver dysfunction. The current research was conducted to show the effect of chrysin on the activities of antioxidant enzyme (catalase, glutathione peroxidase, and superoxide dismutase), serum nitric oxide (NO), and lipid peroxidation as well as inflammatory cytokines (TNF-α, IL-6, and IL-1β) of aging rats. Male Wistar rats of different ages, 2, 10, and 20 months, were randomly divided into six groups as follows (n=8, per each group): young control rats (C2), young CH-treated rats (CH2), middle- aged control rats (C10), middle-aged CH-treated group (CH10), aged control group (C20), and aged CH-treated group (CH20). Chrysin (20 mg/kg) was administered intraperitoneally once a day for 30 days. Present findings indicated that chrysin treatment ameliorated the increased liver levels of lipid peroxidation, TNF-α, and IL-1β as well as serum levels of NO. The findings suggest that chrysin could be effective against the progression of ageinduced damage by modulation of oxidant-antioxidant system and inflammatory response.