Abstract
Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment. Results indicate that chrysin has significant acute antihyperglycemic and antidiabetic effects in nude diabetic mice (p < 0.05). Moreover, triglyceride blood levels were reduced and IL-1β and TNF-α were diminished after 10 days’ treatment compared with control group (p < 0.05). In conclusion, it was found that chrysin could produce similar effects as metformin, a drug used for the treatment of diabetes, since both test samples decreased glucose and triglycerides levels, they impaired the generation of pro-inflammatory cytokines involved in the development of diabetes and its consequences, such as atherosclerosis and other cardiovascular diseases.
Highlights
Type 2 diabetes is a chronic disease characterized by insulin resistance and deficiency of insulin secretion, which could be present at any age and affects more than 300 million people worldwide [1].Despite its epidemiology, an efficient and safety drug for diabetes treatment is still to be developed due to multiple adverse reactions and drug interactions of current treatments [2]
The effects of chrysin on glucose metabolism and inflammation in During current investigation, the effects of chrysin on glucose metabolism and inflammation in athymic nude mice were evaluated. The action of this flavonoid was evaluated in normoglycemic athymic nude mice were evaluated. The action of this flavonoid was evaluated in normoglycemic athymic nude mice to determine its antihyperglycemic effect in glucose and sucrose tolerance tests
The acute evaluation showed that chrysin mg/kg)has hasananantihyperglycaemic antihyperglycaemiceffect, effect,similar similar
Summary
Type 2 diabetes is a chronic disease characterized by insulin resistance and deficiency of insulin secretion, which could be present at any age and affects more than 300 million people worldwide [1].Despite its epidemiology, an efficient and safety drug for diabetes treatment is still to be developed due to multiple adverse reactions and drug interactions of current treatments [2]. The development of new drugs that could control and reduce diabetes complications by deploying other effects, such as pro-inflammatory cytokines, could be useful to improve the outcome of the disease [3]. In this context, natural products are an important source to find a desirable drug for diabetes and the Molecules 2018, 23, 67; doi:10.3390/molecules23010067 www.mdpi.com/journal/molecules Molecules. Anti-inflammatory and antioxidant present in the aerial parts of Oroxylum, Chamomille and Passiflora genus and it is abundant in honey properties and is widely used as nutritional supplement for body-building for its aromatase and propolis. This antidiabetic action could be related to the inhibition of 11βto its increase of antioxidant enzymes and antidyslipidemic activities in experimental diabetic rats [5]
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