Chronotypical characteristics and related miR-142-3p levels of children with attention deficit and hyperactivity disorder

Abstract

To compare children with Attention Deficit and Hyperactivity Disorder (ADHD) and a healthy control group in terms of chronotype characteristics and miRNA-142-3p/miRNA-378 levels. 50 children with ADHD and 44 healthy children were included in the study. Childhood Chronotype Questionnaire was used to identify the chronotype preferences of children. Serum miR-142-3p and miR- 378 levels were determined. Preference for nighttime was higher in children with ADHD. Additionally, a night preference was found to be associated with attention deficit in both groups. While a significant correlation was found between the psychopathology rate in mothers and the presence of ADHD, there was no such correlation in fathers. In the comparison between children with ADHD and the control group, no significant difference was found between miRNA levels. Both the miR-142-3p and miR-378 values of the children with ADHD that have immediate relatives with a psychiatric disorder were lower, compared to control group. We found that shift to night preference in the circadian rhythm was higher and this preference was associated with attention deficit in the children with ADHD. In addition, the presence of psychopathology in the family and the mother's psychopathology affected the miR-142-3p and miR378 levels