Abstract
The chronotropic and inotropic responses were studied in isolated atria and papillary muscles from rats who had carried a pellet of methyl methacrylate polymer for one week and from sham operated control rats. Right atria isolated from implanted rats were hyporesponsive to the positive chronotropic effects of isoproterenol and glucagon but not to dibutyryl cAMP or to CaC12. Inotropic response of left atria and papillary muscles to isoproterenol was unaltered. No change in the beta-receptor density or affinity was associated with these phenomena. The results indicate that methyl methacrylate exposure leads to a disruption in the signal transduction of chronotropic stimuli mediated by the adenylate cyclase system. The alteration occurs at some point after receptor binding and before cAMP action.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
