Chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma

J Ali,J Qureshi,Alka Ahuja,Mohd Amir,Sanjula Baboota

doi:10.4103/0250-474x.43000

Abstract

A time dependent pulsed release system consisting of an effervescent core surrounded by consecutive layers of swelling and rupturable polymers was prepared and evaluated. The cores containing salbutamol sulphate as bioactive agent were prepared by direct compression method using different ratios of microcrystalline cellulose and effervescent agent and then coated sequentially with an inner swelling layer containing a hydrocolloid, hydroxypropylmethylcellulose E5 and an outer rupturable layer having Eudragit RL/RS (1:1). The effects of various processing and formulative parameters on the performance of system were studied. The rupture and dissolution tests were studied using the USP paddle method at 50 rpm in 0.1 N HCl and phosphate buffer pH 6.8. The lag time of the drug release decreased by increasing the inner swelling layer and increased by increasing the rupturing layer level. All the results obtained in the present study suggest that osmotic pumping effect was involved which eventually lead to the drug release.

Highlights

A time dependent pulsed release system consisting of an effervescent core surrounded by consecutive layers of swelling and rupturable polymers was prepared and evaluated
Effect of outer polymer concentration and water uptake performance: To study the effect of outer polymeric layer concentration on lag time, core tablets were coated with different levels of Eudragit RL/ RS (1:1) i.e. 4, 6, 8 and 10% w/w
The rupturable pulsatile drug delivery system consisted of a core, a drug containing reservoir, inner or intermediate swelling layer and an outer water insoluble but permeable coating

Summary

Sulphate for the Treatment of Nocturnal Asthma

The lag time of the drug release decreased by increasing the inner swelling layer and increased by increasing the rupturing layer level. May - June 2008 a lag time of six hours i.e., the system is taken at the bed time and expected to release the drug after a period of 6 h i.e., at 4.00 am when the asthma attacks are more prevalent. Such time-controlled pulsatile delivery can be achieved mainly with drug containing cores, which are covered with release controlling layers.

MATERIALS AND METHODS

RESULTS AND DISCUSSION

Thickness of the swelling layer was the critical

Accelerated stability studies indicated a shelf life of