Abstract
Editorials1 January 1985Chronicity of Epstein-Barr Virus InfectionJAMES C. NIEDERMAN, M.D.JAMES C. NIEDERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-119 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMultiple lines of investigation using serologic, virologic, and immunologic techniques have solidly established that infectious mononucleosis results from a primary infection with Epstein-Barr virus (1-8). A fundamental property of this agent, a member of the herpesvirus group, is its tropism for B lymphocytes of the human host and its unique ability to induce continuous growth of lymphocytes in cell culture (immortalization) (9). In mononucleosis, a characteristic polyclonal B-cell proliferative response is induced.One striking manifestation of lymphoproliferation in infectious mononucleosis is the presence of large numbers of atypical lymphocytes in peripheral blood. Relatively few lymphocytes are actually infected by Epstein-Barr...
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