Abstract
The effect of chronic zolpidem treatment on the steady-state levels of γ-aminobutyric acid A α1–6, β1–3 and γ1–3 subunit mRNAs in rat cortex has been investigated. Male Sprague-Dawley rats were injected once daily, for 7 or 14 days, with 15 mg/kg of zolpidem in sesame oil vehicle. The levels of the α4 and β1 subunit mRNAs were significantly increased after 7 days of treatment and the level of α1 subunit mRNA was significantly decreased after 14 days of treatment, as determined by solution hybridization. These results are compared to the previously determined effects of an equivalent schedule of treatment with diazepam.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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