Abstract
ABSTRACT Background: Acid inhibition from chronic proton pump inhibitor use and a possible increase in gastrin can lead to changes in the regulation of hydrochloric acid production. However, it has not known whether such chronic use changes the presence of gastrin, delta, and enterochromaffin-like cells in the stomach or the relationship between gastrin and delta cells. Aim: To analyze the number of gastrin-producing gastrin cells, somatostatin-producing cells, and histamine-producing cells in patients who were chronic users of proton pump inhibitor, with or without related Helicobacter pylori infection. Methods: Biopsies from 105 patients, including 81 chronic proton pump inhibitor users (experimental group) and 24 controls, were processed immunohistochemically and subjected to counting of gastrin, delta, and enterochromaffin-like cells in high-magnification microscopic fields and in 10 glands. Results: Gastrin cell, delta cell, and enterochromaffin-like cells counts were similar across the groups and appeared to be unaffected by Helicobacter pylori infection. The ratio between gastrin cells and delta cells was higher in the chronic users of proton pump inhibitor group than in controls. Conclusion: Chronic users of proton pump inhibitor does not affect gastrin cell, delta cell, and enterochromaffin-like cell counts significantly, but may alter the ratio between gastrin cells and delta cells.
Highlights
Acid secretion plays an important role in regulating gastric functions
The acid inhibition that occurs with the chronic use of proton pump inhibitors (PPIs) and possible associated increases in gastrin levels may lead to changes in the mechanisms regulating Hydrochloric acid (HCl) production
It is unclear whether their chronic PPI use changes the quantities of G, D, and enterochromaffin-like cells (ECL) cells, or the ratio between G cells and D cells, in these patients
Summary
Acid secretion plays an important role in regulating gastric functions. It protects against pathogenic gastrointestinal agents, facilitates digestion and the absorption of some nutrients, and modulates eating behavior[17,22]. The acid inhibition that occurs with the chronic use of proton pump inhibitors (PPIs) and possible associated increases in gastrin levels may lead to changes in the mechanisms regulating HCl production. It is unclear whether their chronic PPI use changes the quantities of G, D, and ECL cells, or the ratio between G cells and D cells, in these patients. The aim of this research was to analyze the number of gastrin-producing cells, somatostatin-producing cells, and histamine-producing cells in patients who were chronic users of proton pump inhibitor, with or without related Helicobacter pylori infection from the antral and gastric body areas were collected as medically indicated during the endoscopic procedure
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
