Abstract
A monoclonal serum, IgM, was found in five patients with chronic urticaria. There was no overt associated lymphoid malignancy. Skin lesions were accompanied by several other clinical or biologic symptoms: fever, arthralgias, increased sedimentation rate, hyperfibrinogenemia, hyperleukocytosis, and skin vasculitis (three patients). Urticaria was associated neither with significant abnormalities of the complement components, nor with the presence of C1 q precipitins. No significant amount of circulating immune complexes were detected. There were no IgM deposits in the skin. The role of the monoclonal IgM is discussed.
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