Abstract
Background the purpose of this study was to perform a systematic review regarding clinical and histopathological characteristics, immunopathological findings, and treatment for chronic ulcerative stomatitis (CUS). Material and Methods articles in English, published from January 1962 up to November 2017, assessing clinical and immunological features, treatment, and follow-up of patientes with CUS, were retrieved from three databases (PubMed, Cochrane Library and SCOPUS). A manual literature search was also conducted. A total of 12 studies met inclusion criteria, therefore, were analyzed in this review. Results CUS shares similiar clinical and microscopic features to those found in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Hence, direct immunofluorescence (DIF) is indispensable to define a final diagnosis. Due to the poor sample availability in the current literature, it is not possible to accurately confirm the prevalence and features of CUS. Conclusions in order to better evaluate this condition’s findings, further studies with a greater amount of similar immune-mediated diseases should be performed. Key words:Chronic ulcerative stomatitis, immune-mediated diseases, immunofluorescence, lichen planus.
Highlights
Chronic ulcerative stomatitis (CUS) is a poorly understood chronic condition that causes painful, exacerbating, and remitting ulcerations, in oral mucous membranes [1]
Since this condition may be confounded with other autoimmune diseases, especially oral lichen planus (OLP), it is likely that many cases are misdiagnosed [2,3]
Direct immunofluorescence (DIF) of lesional and perilesional specimens shows the presence of autoantibodies with a stratified epithelial specific-antinuclear antibody (SES-ANA) pattern [4]
Summary
Chronic ulcerative stomatitis (CUS) is a poorly understood chronic condition that causes painful, exacerbating, and remitting ulcerations, in oral mucous membranes [1]. No study has systematically evaluated the clinical and histopathological characteristics and the immunofluorescence pattern of CUS. Inclusion criteria for our systematic review were (i) studies describing clinical, histopathological, and immunopathological findings in oral chronic ulcerative stomatitis patients; (ii) cases reports, case series and cross-sectional studies; and (iii) articles published in English.
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