Abstract
Drugs that bind at the σ site have been proposed to have psychotomimetic and/or antipsychotic activity that is independent from that mediated by the phencyclidine (PCP) receptor. Some evidence suggests that σ ligands may produce their effects by modulation of dopamine neurotransmission. The present study examined potential interactions between the σ and dopamine system following chronic treatment with d-pentazocine, a specific σ ligand that has negligible affinity for either PCP or dopamine receptors. Rats treated for one month with either saline or 10 mg/kg per day d-pentazocine revealed no significant differences in either the K D or B max of [ 3H]haloperidol-labeled σ or [ 3H]YM-09151-2-labeled dopamine D 2 receptors across multiple brain regions. These results are discussed in relation to the pharmacology of putative σ-receptor subtypes.
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