Abstract
Thyroid hormones play an essential and critical role for metabolism, growth, and tissue differentiation in chordate. Thyroid dysfunction such as hypothyroidism is a frequent disease in adults, leading to neurological symptoms and emotional disease including depression. The interaction between thyroid hormones and serotonin of central nervous system may account for it. The present study was aimed to determine the expression level of serotonin receptors including 5HT_(1A), 5HT_(2A), 5HT_(2C), 5HT_(3A), and serotonin transporter (SERT) in hippocampus, amygdala, raphe nuclei, and medial prefrontal cortex in the rat after chronic treatment of methimazole (MMI) by using real time PCR. Results showed the mRNA level of 5-HT_(1A) was increased in raphe nuclei and hippocampus of the MMI-treated animals. The mRNA of 5-HT_(2A) receptor was elevated in raphe nuclei, and the mRNA of 5-HT_(2C) receptor and SERT were increased in hippocampus. In conclusion, we found that chronic administration of MMI changes expression of serotonin receptors in the raphe nuclei and limbic system, and could be the reason due to depression.
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