Abstract
THIS STUDY was made because of the conflicting reports in the literature regarding the toxicity of stilbestrol in man and animals. In many of these reports there is no evidence of controlled studies. The doses of stilbestrol are frequently excessive and so far above the calculated therapeutic dose range that the pathological changes reported are of little significance when considering the drug for clinical use. For these reasons this chronic toxicity study of the effects of stilbestrol in various dose ranges and in two different media was conducted. Four oral dose levels of stilbestrol were established for this study on rats as follows. (a) Fifty 7 3 times weekly (7507 weekly/kg. body weight of rat) which is more than 5 times as great as the average human therapeutic dose (1 mg. daily for a 50 kg. person) or corresponds to a weekly dose of 37.5 mg. of stilbestrol for the human being.
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