Abstract
A 74-year-old female was admitted to the Gunma University Hospital for the re-evaluation of anemia and thrombocytopenia in May, 1990. She was already diagnosed as having refractory anemia with ringed sideroblasts 10 months before and had received repeated blood transfusions. Hematologic examinations confirmed her diagnosis but the administration of vitamin B6, anabolic steroid, and vitamin D3 failed to improve her situation. During this period of admission, she was considered to have chronic thyroiditis by positive antithyroid and antimicrosome tests, and decreased serum level of free T3. Positive antiglobulin tests and increased platelet-associated IgG level were considered to be related to multiple blood transfusions. Natural killer activity, and CD16, CD56 and CD57 positive cells were decreased. In addition, the CD4/CD8 ratio was markedly increased and anti-centromere antibody was detected. These findings suggest that there may have been immunologic abnormalities in this case of myelodysplastic syndrome.
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