Abstract
Obesity in men is associated with increases in renal disease. Androgen levels decrease in obese men, and many investigators believe this may contribute to the increased renal disease. The present study was done to test the hypothesis that chronic androgen supplementation protect against renal injury in obese rats. Male lean and obese Zucker rats, aged 24 wks, were untreated (C) or treated with testosterone propionate (5 (5T) or 10 (10T) mg/10 mm Silastic pellets implanted SQ, changed every 3 weeks) for 10 wks. Body weight (BW), GFR, albuminuria, TNF‐α, IL‐6, left ventricular index (LVI) were measured at 34 wks of age. Data shown below.compared with Lean‐C; #, compared with Obese‐CThe data show that chronic testosterone decreases BW, inflammation, renal injury, LVI in obese rats, but decreases renal function and promotes renal injury in lean rats. Men with obesity may benefit from testosterone replacement.
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