Abstract
Describing the neurobiological changes which may explain the link between chronic stressors and the epidemiological association of recurrent episodes of depression in patients with unipolar or bipolar illness is a goal of psychiatric research. Disorders of mood may involve hyperactivity of central muscarinic mechanisms. Chronic forced swim stress and footshock produce supersensitivity to a muscarinic agonist. Chronic prolonged restraint is a severe stressor for the rat and activates the hypothalamic-pituitary-adrenal (HPA) axis. This report presents data suggesting that this stressor does not, unlike forced swim stress and footshock, enhance sensitivity to the hypothermic effects of a muscarinic agonist.
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