Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, inherited auto-inflammatory disease with an unknown genetic cause which predominantly affects children, and is characterized by the insidious onset of periodic bone pain, with or without fever. Diagnosis is difficult and is dependent on the clinical course, imaging, pathology, and microbiology. A large number of drug treatments have been tried with variable success, and medical management includes nonsteroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, azithromycin, tumor necrosis factor α-blocker (infliximab), inter - feron, and oral steroids. Antibiotics are now thought to have a limited role in light of the inflammatory rather than infective nature of the disease. Surgical treatment has been reported, but its role is not yet clearly defined. Here we report two patients who were diagnosed with CRMO presenting to a District General Hospital. Despite receiving differing drug treatments, one of which included the use of antibi - otics, both made a good clinical recovery.
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