Abstract
PURPOSE: Pulmonary complications occur in 30-60% of patients after HSCT, contributing to significant morbidity and mortality. Advances in pre-transplant antimicrobial prophylaxis have shifted concerns among transplant physicians to non-infectious complications, where relatively less progress has been made over the years in improving transplant-related outcomes. In particular, late onset non-infectious pulmonary complications(LONIPCs)including Idiopathic Pneumonia Syndrome(IPS), Bronchiolitis Obliterans(BO)and Bronchiolitis Obliterans Organising Pneumonia(BOOP)may occur and are strongly associated with chronic pulmonary GVHD.
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