Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity

Robert A Mccutcheon,Michael A.P Bloomfield,Tarik Dahoun,Mitul Mehta,Oliver D Howes

doi:10.1016/j.schres.2018.12.011

Abstract

Psychosocial stressors including childhood adversity, migration, and living in an urban environment, have been associated with several psychiatric disorders, including psychotic disorders. The neural and psychological mechanisms mediating this relationship remain unclear. In parallel, alterations in corticostriatal connectivity and abnormalities in the processing of salience, are seen in psychotic disorders. Aberrant functioning of these mechanisms secondary to chronic stress exposure, could help explain how common environmental exposures are associated with a diverse range of symptoms. In the current study, we recruited two groups of adults, one with a high degree of exposure to chronic psychosocial stressors (the exposed group, n = 20), and one with minimal exposure (the unexposed group, n = 22). All participants underwent a resting state MRI scan, completed the Aberrant Salience Inventory, and performed a behavioural task – the Salience Attribution Test (SAT). The exposed group showed reduced explicit adaptive salience scores (cohen's d = 0.69, p = 0.03) and increased aberrant salience inventory scores (d = 0.65, p = 0.04). The exposed group also showed increased corticostriatal connectivity between the ventral striatum and brain regions previously implicated in salience processing. Corticostriatal connectivity in these regions negatively correlated with SAT explicit adaptive salience (r = −0.48, p = 0.001), and positively correlated with aberrant salience inventory scores (r = 0.42, p = 0.006). Furthermore, in a mediation analysis there was tentative evidence that differences in striato-cortical connectivity mediated the group differences in salience scores.

Highlights

Several environmental factors that can be considered chronic psychosocial stressors are associated with an increased risk of developing schizophrenia, but the psychological and neurobiological mechanisms mediating this increased risk remain incompletely understood (Tost et al, 2015)
We demonstrated reduced adaptive salience in individuals that had been exposed to chronic psychosocial stressors, and found that this was related to increased connectivity between striatal seeds and cortical regions involved in salience processing
Ventral striatum play a central role in this process (Schlagenhauf et al, 2013; Schultz et al, 1997), and impaired dopaminergic reward signalling secondary to chronic stress has been put forward as one of the neurochemical alterations contributing to affective (Cabib and PuglisiAllegra, 2012; Chen et al, 2015) and psychotic disorders (Howes et al, 2017)

Summary

Introduction

Several environmental factors that can be considered chronic psychosocial stressors are associated with an increased risk of developing schizophrenia, but the psychological and neurobiological mechanisms mediating this increased risk remain incompletely understood (Tost et al, 2015). Disruption in salience processing has been proposed as a central deficit in schizophrenia, whereby the ‘salience’ of a stimulus refers to the significance that stimulus holds for an organism (Winton-Brown et al, 2014). Corticostriatal circuits play an important role in salience processing, and disruption of these circuits is seen in schizophrenia (Dandash et al, 2014; Fornito et al, 2013; Levitt et al, 2017). We investigated whether exposure to chronic psychosocial stressors was associated with alterations in salience processing, and whether this was linked to changes in corticostriatal connectivity.

Methods

Results

Conclusion