Abstract
In this article the role of neurobiological, psychological and social factors in pathogenesis of chronic pain is analyzed. The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity. The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels--from peripheral neuron to central structures--that provides pain perception and painful behaviour development.
Highlights
Хроническая боль также увеличивает риск смерти янием, которое оказывает существенное влияние на рабо- независимо от социально-демографических факторов тоспособность, функциональную активность и каче- [5]
The chronic pain is considered not as a symptom of damage of tissue and as independent illness due to non-adequate neuroplasticity of systems involved into regulation of pain sensitivity
The major role in development and maintenance of chronic pain is devoted to the primary genetically determined and/or secondary disturbance of interaction between nociceptive and antinociceptive systems at various levels - from peripheral neuron to central structures – that provides pain perception and painful behaviour development
Summary
Хроническая боль также увеличивает риск смерти янием, которое оказывает существенное влияние на рабо- независимо от социально-демографических факторов тоспособность, функциональную активность и каче- [5]. При этом идентификация и устранение повреж- мости ноцицептивных нейронов в задних рогах спинного дения не всегда сопровождается исчезновением болевого мозга и других структурах центральной нервной системы синдрома, и не обязательно прослеживается прямая связь (ЦНС).
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