Abstract
Data are given on the effects of the oral administration of alkyl dimethyl benzyl ammonium chloride, sodium dioctyl sulfosuccinate, and sodium lauryl sulfate for two years and the oral administration of sodium lauryl sulfate, sodium dioctyl sulfosuccinate, sodium alkyl aryl sulfonate, polyethylene glycol monoisooctyl phenol ether, and sulfoethyl methyl olylamide for four months. The results of the chronic study indicate a high degree of toxicity for alkyl dimethyl benzyl ammonium chloride. It was toxic to rats at a concentration of 0.063% or more in the diet. Sodium dioctyl sulfosuccinate was slightly toxic at a concentration of 1%. Sodium lauryl sulfate showed no toxic effect at a dosage level of 1%. In the subacute experiment sodium dioctyl sulfosuccinate was toxic at all dosages, sodium lauryl sulfate decreased the growth rate at the 4% concentration, and the other three surface-active agents produced an effect on growth at the 2% concentration.
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