Abstract
Patients with chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) share common risk factors. However, there is limited information about COPD and CKD. This is case-cohort study was carried out using the Taiwanese National Health Insurance Research Database to evaluate the correlation between COPD and CKD. We identified cases aged older than 40 years who had an inpatient hospitalization with a first-time COPD diagnosis between 1998 and 2008. Control were selected from hospitalized patients without COPD or CKD and were matched according to age, gender, and year of admission at a 2:1 ratio. Cox proportional hazards model was used to assess the association of CKD and COPD. The overall incidence of CKD was higher in the COPD group (470.9 per 104 person-years) than in the non-COPD group (287.52 per 104 person-years). The adjusted hazard ratio of case was 1.61 (P < 0.0001) times that of control. COPD was found to be associated with kidney disease from our follow-up. To detect CKD early, early diagnosis of CKD in patients with COPD and prompt initiation of monitoring and treatment are imperative.
Highlights
Patients with chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) share common risk factors
Stroke, coronary artery disease (CAD), hyperlipidemia, hypertension, diabetes, cancer, peripheral vascular disease (PVD), chronic liver disease, gout, sleep apnea were more prevalent in patients with COPD
The present study is the first nationwide population-based study to address the association between COPD and CKD, and we provided the incidence rate of CKD in patients with COPD with a long-term follow-up period
Summary
Patients with chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) share common risk factors. Patients with COPD have a higher risk of comorbidities, including lung cancer, pulmonary tuberculosis, dementia, and coronary artery disease (CAD)[1,2,3]. These comorbidities may contribute to systemic inflammation in patients with COPD. Patients with COPD and chronic kidney disease (CKD) share common risk factors, including diabetes and hypertension[4,5,6,7,8,9,10].
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