Abstract
The research of the main epidemiologic parameters of chronic obstructive pulmonary disease have been carried out within the study using the analytical method of research of evidence based medicine data bases, namely ACP Journal Club, Cochrane Library, Clinical Evedence, PubMed and others. The results of the research have shown that the main epidemiologic parameters of COPD, such as prevalence, morbidity and mortality vary considerably in different countries and sub-populations within a country and usually depend on the tobacco prevalence. The results of this research have shown that the average prevalence rate of COPD within the general population is registered at the level of 7.6%, while for smokers this index reaches 15.4%. The share of COPD in the structure of respiratory diseases was about 11% in Ukraine within the period of 2007-2011. According to the WHO data chronic obstructive pulmonary disease took the fourth position among TOP-10 causes of death in the world – 5.8% of all lethal cases in 2011. Lethality of COPD is about 60% of the total lethality cases in Ukraine. At present COPD is one of the main causes of morbidity and lethality all over the world, which results in a great economic and social loss. According to the WHO by 2020 COPD will have taken the fifth place in the world by the level of economic and social damage.
Highlights
Chronic obstructive pulmonary disease (COPD) is a primary chronic inflammatory disease affecting mainly the distal parts of the respiratory tract and lung parenchyma with formation of emphysema, bronchial patency obstruction with partially or completely irreversible bronchial obstruction development caused by the inflammatory response [3]
Peripheral bronchial obstruction, parenchyma destruction, and pulmonary vascular lesions reduce the ability of the lungs to adequate gas exchange, the ratio of ventilation – perfusion increases, first hypoxemia develops and hypercapnia
Hypoxemia at early stages appears with physical load, later it is observed at rest
Summary
In the course of the research the analytical method was used to study the evidence-based medicine databases, namely ACP Journal Club, Cochrane Library, Clinical Evedence, PubMed, Best Evidence, UpToDate, Evidence-bacedmedicine (OVID), Scientific American Medicine with the purpose to review and analyze the basic epidemiological characteristics of chronic obstructive pulmonary disease worldwide and in Ukraine, in particular
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