Abstract
The article presents the current data on the pathogenesis, features of clinical manifestations, and diagnostics of different variants of chronic non-bacterial («sterile») osteomyelitis (CNO). The inherited forms of the disease, such as syndromes of deficiency of the interleukin-1 receptor antagonist (DIRA), sterile pyarthrosis with pyoderma gangrenosum and acne (PAPA-syndrome), dyserythropoietic anemia with chronic non-bacterial osteomyelitis (Majeed-syndrome) are described. The pathogenesis of CNO and related diseases is based on hyperproduction of proinflammatory cytokines, particularly of interleukin-1 β and tumor necrosis factor- α . Based on the literature data and our own observations, the recommendations for diagnostics and treatment of CNO are presented.
Highlights
The article presents the current data on the pathogenesis, features of clinical manifestations, and diagnostics of different variants of chronic non-bacterial («sterile») osteomyelitis (CNO)
The pathogenesis of chronic non-bacterial (sterile) osteomyelitis (CNO) and related diseases is based on hyperproduction of proinflammatory cytokines, of interleukin-1 and tumor necrosis factor-␣
Чувствительность стандартной субхондральной эрозии и остеосклероза дистального метафиза рентгенографии для оценки костной деструкции в сравбольшеберцовой кости); Б — МРТ грудного отдела позвоночника; В — рентгенограмма плечевого сустава
Summary
Ю. Хронический небактериальный («стерильный») остеомиелит в практике детского ревматолога, современные подходы к диагностике и лечению: обзор литературы и анализ собственных данных. Chronic Non-Bacterial («Sterile») Osteomyelitis in the Practice of Pediatric Rheumatologist, the Contemporary Diagnostic and Treatment Approaches: Literature Review and Own Data Analysis. The article presents the current data on the pathogenesis, features of clinical manifestations, and diagnostics of different variants of chronic non-bacterial («sterile») osteomyelitis (CNO). M., Mushkin A.Yu. Chronic Non-Bacterial (“Sterile”) Osteomyelitis in the Practice of Pediatric Rheumatologist, the Contemporary Diagnostic and Treatment Approaches: Literature Review and Own Data Analysis. ППП — ладонно-подошвенный пустулез; DIRA — синдром дефицита антагониста рецептора интерлейкина 1; SAPHO — по этой патологии [5].
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